Clean room contruction for hospitals plays a crucial role in protecting patient health and enhancing the quality of healthcare services. So, what benefits and applications does clean room construction bring? Let’s explore this in the following article with Puritrak!

1. What is Hospital Cleanroom Construction?

Clean room contruction for hospitals involves using specialized techniques in the construction field to create a clean room that controls factors such as dust, temperature, humidity, and pressure. This ensures a sterile environment for treatment, research, manufacturing, and production.

2. Standards for Clean Rooms In Hospitals

Several standards are applied in clean rooms:

– International Standards: ISO 14644-1, FED STD 209E.

– GMP Standards: WHO GMP, EU GMP: Applied in clean rooms of pharmaceutical production facilities and hospitals.

– OSHA Standards: Occupational Safety and Health Administration (OSHA).

Other Standards in Vietnam: 

– Standard 4088 – 1985: Climatic data in construction design.

– TCVN 5687 – 1992: Ventilation design, air regulation, heating.

– TCVN 2622 – 1995: Standards for fire prevention and protection for buildings and structures.

3. Benefits of Hospital Cleanroom Construction

Clean room contruction for hospitals not only meets technical requirements but also brings numerous practical benefits for both patients and healthcare staff. Here are some notable advantages:

3.1. Infection Prevention

One of the most important benefits of clean rooms is their ability to prevent infections. By controlling microbial dust particles, the concentration of particles in the air is managed without affecting temperature, humidity, and pressure. This ensures a sterile environment that prevents infections, with bacteria unable to invade the clean room space.

3.2. Protecting the Health of Patients and Healthcare Staff

Clean rooms play a key role in protecting the health of both patients and healthcare staff. In operating rooms and intensive care units, controlling air quality and minimizing contamination is critically important. Clean rooms help significantly reduce the risk of infections, bacteria, and harmful pathogens from entering the surgical environment, thus safeguarding both patients and medical staff.

3.3. Ensuring Safe Medical Procedures

Currently, the Ministry of Health places a high priority on clean room standards. The installation of clean room systems ensures safe medical procedures, which are essential during medical examinations and treatments. Therefore, the construction of clean rooms must be executed precisely, with strict control over dust, bacteria, and humidity, allowing medical equipment to operate effectively without external interference.

4. Clean Room Construction Process

Step 1: Receive requests from the hospital and conduct a survey of the area designated for the clean room installation.

Step 2: Design the clean room layout, which will be discussed in detail with the hospital representatives regarding the construction process, including schedule, budget, structural factors, area, air circulation levels, pressure, and necessary technical documents.

Step 3: Proceed with the clean room construction using specialized equipment and materials, adhering to the strict requirements of hospital clean room standards.

Step 4: Conduct a final inspection before the clean room is put into operation.

Step 5: Maintain and manage the clean room facility.

5. Technology and Equipment in Clean Rooms

Technology and equipment in clean rooms play a crucial role in maintaining a sterile and safe environment. Below are the main technologies and equipment commonly used in clean rooms:

5.1. Air Ventilation and Filtration Systems

Ventilation System: Designed to ensure continuous airflow, helping to remove dust and bacteria. This system typically includes fans, ducts, and airflow control devices.

HEPA Filters: Utilize High-Efficiency Particulate Air (HEPA) filters that can remove at least 99.97% of particles sized 0.3 microns. These filters are highly effective in trapping bacteria, viruses, and fine dust.

5.2. Air Conditioning Systems

Air Conditioners: Used to maintain stable temperature and humidity levels in the clean room. Temperature and humidity must be tightly controlled to ensure an appropriate environment for medical procedures.

Temperature and Humidity Control Systems: Utilize sensors to monitor and adjust temperature and humidity as required.

5.3. Monitoring Equipment

 Air Quality Meters: Used to monitor dust, microorganisms, and pollutants in the air. These devices help detect early increases in contaminants and enable timely interventions.

 Automated Monitoring Systems: These systems can automatically alert when parameters exceed allowed limits, ensuring safety for patients and healthcare staff.

5.4. Construction Materials

 Wall and Ceiling Panels: Use moisture-resistant plastic or metal panels that are easy to clean and antibacterial. These materials help prevent the growth of mold and bacteria.

Vinyl or Epoxy Flooring: Select slip-resistant and easy-to-clean flooring materials to maintain hygiene and safety for users.

6. Clean Room Construction Units for Hospitals

Today, it is not difficult to find a unit that designs and constructs clean rooms. However, choosing a reputable unit that ensures quality design and construction requires thorough research.

Puritrak is a trusted clean room construction unit for many clients, featuring a standard air filtration system.

– Utilizes advanced air filtration technology, removing 99.97% of particles and ultra-fine bacteria as small as 0.3 microns.

– Flexible air filtration system, featuring both localized and centralized filtration, meeting clean room standards for all critical areas such as operating rooms, ICUs, and treatment areas.

– UV-C technology for disinfection, using specialized ultraviolet rays to effectively neutralize bacteria and viruses, reducing the risk of cross-contamination.

– Smart operation with automatic adjustments, minimizing manual intervention and optimizing processes, helping hospitals maintain a sterile environment efficiently while saving manpower.

See more: Puritrak Airsen AS488 air purifier

Clean room contruction for hospitals is an essential process that directly impacts the quality of healthcare and patient safety. Building a sterile space that is designed and constructed to standards not only prevents infections but also enhances the effectiveness of medical procedures.

Puritrak products and services:

• Puritrak air purifier
• Puritrak indoor air quality measuring device
• Puritrak outdoor air quality measuring device
• AQM solution

Contact info:

• Hotline: 0904.800.006
• Website: puritrak.com
• Email: Info@puritrak.vn
• Fanpage: Puritrak

Clean rooms in hospitals play a crucial role in controlling infection and ensuring an aseptic environment for healthcare activities1. In 2025, cleanroom standards will be more strictly updated to improve the air quality. So, let’s follow this write to update detailed information.

1. Introduction of clean rooms

1.1. The concept of clean rooms

Clean rooms are specialized areas in the hospitals, which can strictly control various factors such as dust particle, density and size, temperature, humidity, pressure, and cross-contamination risk. Clean rooms are often adopted in the operating rooms, minor surgery rooms, and sterilization areas with air purification systems and infection control measures that extend from the room’s entrance to medical instruments, ensuring to meet strict medical hygiene standards.

1.2. The importance of clean rooms in the medical environment

Clean rooms in the hospitals ensure an aseptic environment, preventing infections for the patients’ surgical areas, helping to increase the success rate of surgery, and protecting the health of patients and doctors. The Ministry of Health emphasizes clean room systems in the operating rooms and treatment areas.

Furthermore, clean rooms are also important in the pharmaceutical and medical food production, preventing pollution, and ensuring the quality of products. This is the key factor to enhance the effectiveness of treatments and constructing safe healthcare systems.

1.3. The benefits of clean rooms for patients and healthcare workers’ health

For patients, the aseptic environment helps to decrease the risk of infections, especially in surgery and treatment of severe diseases.

For healthcare workers, clean rooms facilitate safe working, limiting contact with bacteria and toxic chemicals due to modern air filters. This contributes to leveraging the quality of healthcare and ensuring an effective working environment.

2. The 2025 latest standards for clean rooms

2.1. International standard

• ISO 14644-1: The international standard for clean rooms, regulating cleanliness level from ISO Class 1 to ISO Class 9 based on the quantity of dust particles in the air. This is widely applied in many sectors such as pharmaceutical products, microelectronics, healthcare, and high technology production.
• GMP WHO: The World Health Organization ( WHO )’s guideline for implementing good production requires controlling the quality, manufacturing environment conditions, and the process of ensuring the safety and effectiveness of pharmaceutical products.
• GMP EU: The GMP standard of the EU has stricter regulations than that of the GMP WHO, especially in aseptic production. Clean rooms are categorized according to Grades A, B, C, and D, which are equivalent to levels of controlling dust and microbes.
• FDA: GMP Standard of Food and Drug Administration ( FDA ) requires enterprises to continuously update technologies and processes to ensure safe and qualified products. This is applied in many sectors such as pharmaceutical products, food, and medical equipment.

2.2. Vietnam’s standard

• Climate data for construction design: Standard 4088-1985
• Design of automatic sliding doors for ventilation, air regulation, and heating: Standard TCVN 5687-1992
• Fire prevention and protection standards for buildings and structures: Standard TCVN 2622 – 1995

2.3. Cleanliness levels for different areas in hospitals

• Operating room: The area requires an extremely high level of cleanliness. The proposed cleanliness level for operating rooms is ISO 5 – ISO 7, equivalent to Class 100 – Class 10.000. Today, most operating rooms in hospitals are at Class 10.000.
• Minor Surgery Room: Currently, minor surgery rooms are typically at Class 100.000, equivalent to ISO 8.
• Surgical Corridor: Typically designed at Class 100.000 cleanliness level.
• Sterile Area: Controlled environment.
• Recovery Room: Controlled environment.
• ICU, CCU: Controlled environment.

3. Technical requirements for clean rooms in hospitals.

3.1. Air Filtration System

• HEPA Filter (High-Efficiency Particulate Air): Removes at least 99.97% of dust particles ≥0.3 micrometers in size.
• ULPA Filter (Ultra-Low Penetration Air): Removes up to 99.999% of dust particles ≥0.12 micrometers in size.

3.2. Room Pressure

• Positive Pressure Room: Prevents contaminated air from entering and is applied to operating rooms and sterile areas.
• Negative Pressure Room: Prevents infectious air from spreading outside; used in isolation rooms for contagious diseases.

3.3. Temperature, Humidity, and Ventilation

• Temperature: Maintained between 21°C and 26°C.
• Relative Humidity: Between 60% and 70%.
• Ventilation: Air exchange rate of 15 to 20 times per hour.

3.4. Antimicrobial Building Materials and Surfaces:

•  Use smooth, waterproof, easy-to-clean, and antibacterial materials for walls, floors, and ceilings.
•  Rounded corners to prevent dust and bacteria accumulation.

3.5. Pollution Control System:

• Use monitoring and control equipment to track air dust, bacteria, and chemical levels.
• Ensure compliance with air cleanliness standards, such as ISO 14644-1 and TCVN 8664-1:2011.

4. Applications of Clean Rooms in Hospitals

4.1. Operating Rooms and Emergency Recovery Units

Ensure a sterile environment, reducing the risk of infections during surgeries and critical patient care.

4.2. Intensive Care Units (ICU, NICU)

Provide clean air for patients with weakened immune systems, minimizing the risk of infections.

4.3. Laboratories and Pharmaceutical Production

Control bacteria and dust levels to ensure accurate testing and maintain the quality of medicines and medical devices.

4.4. Infectious Disease Isolation Rooms

Prevent the spread of bacteria and viruses using negative pressure systems and specialized air filtration.

4.5. General Patient Rooms

Improve air quality, helping patients recover better and reducing the risk of cross-infection.

5. Solutions for Achieving Hospital Clean Room Standards

5.1 Selecting an appropriate air filtration system

The air filtration system plays a crucial role in removing fine dust, bacteria, and viruses from the air. Equipment such as HEPA air purifiers and HVAC systems with high-efficiency filters help ensure that clean air meets hospital standards.

Read more: Puritrak Airsen AS800 air purifier

5.2. Cleaning procedures and regular inspections

Regularly clean and maintain the air filtration system. Replace filters on time and monitor air quality to maintain a fresh environment and minimize infection risks.

5.3. Solutions to Improve Air Quality in Hospitals

In addition to filtration systems, integrate air quality sensors, humidity control, and UV-C disinfection to enhance efficiency.

5.4. Technologies and Equipment for Compliance

Utilize advanced technologies such as electrostatic filtration, ionization, controlled ozone, and positive/negative pressure ventilation to optimize air quality in critical areas like operating rooms and intensive care units.

Hospital cleanrooms serve a vital function in preventing infections, protecting patients and medical staff, and improving treatment quality. Implementing cleanroom standards, including air filtration, sanitation, and environmental control, helps minimize the risk of cross-contamination. Investing in modern equipment, such as the Airsen AS800 air purifier with an advanced HEPA filter, creates a clean and safe environment, reduces allergy symptoms, and enhances patient health protection.

Puritrak products and services:

Puritrak air purifier

Puritrak indoor air quality measuring device

Puritrak outdoor air quality measuring device

AQM solution

Contact info:

• Hotline: 0904.800.006
• Website: puritrak.com
• Email: Info@puritrak.vn
• Fanpage: Puritrak

In the hospital environment, infection control plays an important role in protecting the health of patients and medical staff. Hospital cleanrooms are a key solution for minimizing the risk of infection. So what are hospital cleanrooms used for? Assessed on what standards? Let’s find out in the article below!

1. What are hospital cleanrooms?

Hospital cleanrooms are designed to minimize dust particles’ penetration into the air while controlling certain other parameters, such as humidity, pressure, and temperature, when necessary. This control helps reduce the risk of infection or cross-contamination and ensures sterile conditions.

Hospital cleanrooms are designed to control contamination and maintain a sterile environment. This is achieved by practicing strict hygiene protocols, including separating clean areas from other hospital activities. Key measures include providing HEPA-filtered air and precisely controlling pressure, humidity, and temperature to prevent cross-contamination.

2. What are hospital cleanrooms used for?

Cleanrooms in hospitals play a crucial role in infection control, ensuring safety for patients, medical staff, and the surrounding environment. The main functions of hospital clean rooms include:

– Preventing cross-infection between patients, medical staff, and the environment is crucial. Cross-infection is a leading cause of hospital-acquired infections. Cleanroom systems effectively reduce the spread of bacteria, viruses, and pathogens through meticulous air quality control.

– Vulnerable patients, including those with weakened immune systems like cancer patients undergoing chemotherapy, post-organ transplant recipients, and premature births, are susceptible to infections from their surroundings. Therefore, hospitals employ cleanrooms with specialized air filtration systems. These systems prevent contaminated air from entering, ensuring a safe and clean environment for these patients.

– The isolation of patients with contagious diseases is paramount in hospital settings, aiming to prevent the dissemination of pathogens. Cleanrooms are crucial for patients with conditions such as tuberculosis, SARS, COVID-19, or severe influenza. They serve as a critical barrier, preventing the escape and dissemination of infectious agents. Negative pressure rooms and air filtration systems within these rooms ensure that bacteria and viruses are contained, effectively controlling outbreaks.

– Maintaining a sterile environment during surgery and specialized treatments. Operating rooms demand the most stringent hygiene standards within a hospital setting. Surgical infections can result in severe complications for patients. Clean rooms play a vital role in controlling air quality, effectively removing bacteria, dust, and particulate matter that pose infection risks.

3. The standards of hospital cleanrooms

Hospital cleanrooms are designed to ensure a clean, dust-free, and contamination-free environment. When designing these rooms, it is essential to comply with standards such as ISO 14644-1, and FED STD 209E. Cleanrooms in the medical industry must also adhere to GMP standards, including EU GMP and WHO GMP. FED STD 209E is an older standard that is sometimes referenced.

In addition, hospital cleanrooms in Vietnam must adhere to the following national standards:

– Climate data for construction design: Standard 4088-1985

– Ventilation, air conditioning, and heating system design: Standard TCVN 5687-1992

– Fire prevention and firefighting standards for buildings: Standard TCVN 2622-1995

According to the ISO 14644-1 cleanroom standard, a cleanroom is an environment where airborne particle concentration is controlled to a low level. Cleanrooms are classified from ISO 1 to ISO 9, based on the maximum allowable concentration of particles per cubic meter or cubic foot. ISO 8 is among the lower cleanroom classifications and is considered one of the less stringent classes within the standard.

For instance, the airborne particle concentration in a typical office is 5-10 times higher than in an ISO 8 patient room. Furthermore, microbial count assessments in specialized hospital rooms across Vietnam reveal significantly compromised air quality. These assessments demonstrate that air quality frequently reaches, and in some instances falls below, the minimum acceptable standards.

Related Articles: The latest 2025 standard for cleanrooms

4. Classification of cleanrooms

Not every area in a hospital needs a controlled environment. However, certain areas require strict controls, and the following cleanliness levels apply to each room/area:

Operating rooms: demand a high level of cleanliness. In Vietnam, they must adhere to ISO 7 standards, equivalent to Class 10,000, which stipulates a maximum of 325,000 particles of 0.5 microns or larger per cubic meter of air. For advanced operating rooms, ISO 5 standards, equivalent to Class 100, are required, limiting suspended particle counts to 3,520 particles or fewer per cubic meter.

Operating rooms are critical to patient safety, as minimizing surgical site infections and severe medical complications is paramount. Therefore, adherence to specific construction standards is essential for all hospitals.

Maintaining sterility in operating rooms requires a clean air handling system, such as Blower Filter Units (BFUs), to prevent the ingress of dust and bacteria. Air is pre-treated with UV-C irradiation prior to HEPA filtration to enhance its efficiency. Air exchange rates, which vary from 15 to 20-25 air changes per hour, are determined by the specific room type.

This approach mitigates the risk of infection during and following surgical procedures. Maintaining a sterile environment within the operating room is crucial to minimize postoperative infections, which directly impact treatment outcomes and patient recovery time.

Minor surgery room: The minor surgery room meets ISO 8 equivalent to Class 100,000.

Operating corridor: The operating corridor is usually designed at ISO 8 or Class 100,000 cleanliness level.

ICUs: Intensive Care Units (ICUs) in hospitals require a strictly controlled air cleanliness environment to protect patients from infection, particularly in isolation ICUs. These rooms typically adhere to ISO 7 or 8 standards, depending on the specific ICU type.

Hospital rooms: Hospital rooms have less stringent cleanliness requirements compared to operating rooms and ICUs. However, air quality control remains essential to prevent cross-infection. Cleanliness standards for patient rooms typically range from ISO 8 to ISO 7.

To maintain optimal air quality and minimize infection risks, patient rooms in hospitals are equipped with HEPA filtration systems. General patient rooms require an air exchange rate of 4 to 6 air changes per hour, while isolation rooms, requiring a higher level of protection, necessitate 6 to 12 air changes per hour.

Maintaining optimal air quality is vital within hospital environments. Airborne dust particles, bacteria, and viruses pose significant health risks to both patients and medical personnel.

Sterile area: Controlled area 

Resuscitation rooms: Controlled area

Related Articles: Air Purifier Airsen AS488, AS800

5. Hospital cleanroom construction unit

Puritrak is a hospital cleanroom construction unit that meets stringent hospital standards. After carefully researching the clean room location and accompanying equipment, Puritrak begins construction in 5 key steps:

Step 1: Client Requirement Assessment: Puritrak meticulously assesses client requirements and conducts thorough site surveys to determine precise installation parameters.

Step 2: Design Review and Approval: Detailed design reviews are conducted, and necessary refinements are made, culminating in formal client approval prior to implementation.

Step 3: Construction Execution: Utilizing specialized materials and adhering to strict quality control measures, Puritrak executes construction in full compliance with relevant hospital standards.

Step 4: Pre-Operational Inspection and Acceptance: Rigorous inspections are performed to ensure compliance with design specifications and operational requirements, followed by formal client acceptance.

Step 5: Warranty and Maintenance Services: Puritrak provides comprehensive warranty and maintenance services for cleanroom construction and associated equipment, including cleanroom equipment such as Pass Boxes, AHUs, Air Shower, and FFUs, and laboratory equipment such as Biological Safety Cabinets, Laminar Flow Hoods, and Dispensing Booths.

Related Articles: Clean Room Construction for Hospitals

A hospital cleanroom is an environment that is rigorously controlled in terms of dust particles, microorganisms, humidity, pressure, and temperature. The purpose of the cleanroom is to minimize the risk of infection, and cross-infection, create a sterile environment, and ensure the safety of patients and medical staff.

Understanding the importance of hospital cleanrooms is vital for ensuring patient and staff safety.

If you require advice on air filtration systems, please contact the information below. Puritrak’s highly trained technical team is ready to support and answer any questions. Thank you for your interest!

Puritrak products and services:

Puritrak air purifier

Puritrak indoor air quality measuring device

Puritrak outdoor air quality measuring device

AQM solution

Contact info:

• Hotline: 0904.800.006
• Website: puritrak.com
• Email: Info@puritrak.vn
• Fanpage: Puritrak